Hematopoietic Cell Expansion and Ring1B Unveils an Antiproliferative Role in Inactivation of the Polycomb Group Protein
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Published Ahead of Print 26 November 2007. 10.1128/MCB.01136-07. 2008, 28(3):1018. DOI: Mol. Cell. Biol. Haruhiko Koseki and Miguel Vidal Serrano, Teresa Melgar, Mitsuhiro Endoh, Claudia Pérez, Carmela Calés, Mónica Román-Trufero, Leticia Pavón, Iván Deletion Ink4a Associated with Cooperation with Tumorigenesis Hematopoietic Cell Expansion and Ring1B Unveils an Antiproliferative Role in Inactivation of the Polycomb Group Protein
منابع مشابه
Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion.
Polycomb group (PcG) proteins act as positive regulators of cell proliferation. Ring1B is a PcG gene essential for embryonic development, but its contribution to cell turnover in regenerating tissues in not known. Here, we have generated a conditional mouse mutant line to study the Ring1B role in adult hematopoiesis. Mutant mice developed a hypocellular bone marrow that paradoxically contained ...
متن کاملRing1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells
The Polycomb group (PcG) gene Ring1B has been implicated in the repression of developmental control genes and X inactivation and is essential for embryogenesis. Ring1B protein contains a RING finger domain and functions as an E3 ubiquitin ligase that is crucial for the monoubiquitination of histone H2A (H2AK119ub1). Here, we study the function of Ring1B in mouse embryonic stem (ES) cells. The d...
متن کاملThe Polycomb Protein and E3 Ubiquitin Ligase Ring1B Harbors an IRES in its Highly Conserved 5′ UTR
Ring1B is an essential member of the highly conserved Polycomb group proteins, which orchestrate developmental processes, cell growth and stem cell fate by modifying local chromatin structure. Ring1B was found to be the E3 ligase that monoubiquitinates histone H2A, which adds a new level of chromatin modification to Polycomb group proteins. Here we report that Ring1B belongs to the exclusive gr...
متن کاملStructure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex.
Polycomb group proteins Bmi-1 and Ring1B are core subunits of the PRC1 complex, which plays important roles in the regulation of Hox gene expression, X-chromosome inactivation, tumorigenesis, and stem cell self-renewal. The RING finger protein Ring1B is an E3 ligase that participates in the ubiquitination of lysine 119 of histone H2A, and the binding of Bmi-1 stimulates the E3 ligase activity. ...
متن کاملRegulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome.
The polycomb repressive complex (PRC) 1 protein Ring1B is an ubiquitin ligase that modifies nucleosomal histone H2A, a modification which plays a critical role in regulation of gene expression. We have shown that self-ubiquitination of Ring1B generates multiply branched, "noncanonical" polyubiquitin chains that do not target the ligase for degradation, but rather stimulate its activity toward h...
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تاریخ انتشار 2007